Everyone knows about the superheroes Deadpool has beaten, many of whom were courtesy of Deadpool’s killing spree against the Marvel Universe. However, this is not one-sided. Just because he has a healing factor doesn’t mean he can’t lose; it simply means his opponent has to get creative to find a way to keep him down. And quite a few opponents have managed to do just that.

  • When the Marvel Cinematic Universe revealed that they were bringing back Deadpool and the third movie would be under the MCU banner, it made fans very excited. However, Ryan Reynolds knows what fans want, and he created a frenzy when he recently announced that the movie would also see the arrival of Wolverine, and Hugh Jackman would reprise the role. As Marvel Comics fans know, Wolverine is someone who has not only fought Deadpool many times, but is someone who has many victories over the Merc with a Mouth. Expect them to fight together and against each other when the new movie comes out from the MCU.

Since Deadpool knows he’s a comic book character, he doesn’t take most fights too personally. In fact, many of the heroes who beat him he considers friends. Plus if he has to lose to someone, Deadpool couldn’t pick many better options than the ones who have beaten him. He’s been taken out by some of the biggest names in comics.

Spider-Man

Deadpool loves to have a buddy along for his adventures and has a long history of teaming up with not only Wolverine, but also Spider-Man. Of course, Deadpool’s sense of fun differs quite a bit from a lot of other heroes, so he also has no qualms about fighting his allies. In the Ultimate Spider-Man cartoon, that’s exactly what happened.

It’s hard to tell if Deadpool was even serious about winning since he seemed to have so much fun using puns to attack Peter. Thanks to an overactive imagination, Deadpool pulled Spider-Man into his fantasies. It was obvious neither hero was taking this seriously enough to go for the kill, and were just using the physicality of their fight to see who had more witty one-liners. Eventually, Spider-Man learned how the game worked, and threw a literal book of morals at Deadpool to score the knock-out.

Wolverine

Wolverine and Deadpool have fought a lot over the years. Their opposing personalities have made for some great buddy adventures together, but their healing factors also made them the perfect opponents. Deadpool has definitely gotten the better of Logan before, but one of Wade’s losses has also been one his most embarrassing and well-known. Unfortunately, Deadpool had to start out in X-Men Origins: Wolverine.

For starters, this Deadpool looked nothing like his comic book self. Even his mouth was fused together, which was baffling when Wade’s humor is one of his best traits. Regardless, this Deadpool received an upgrade in powers, not only having regeneration, but also retractable swords in his arms, the power to teleport, and laser vision like Cyclops. Wolverine and Sabretooth had to double-team him to get the upper hand, but once Wade was distracted, Logan had a clean shot to decapitate him.

Squirrel Girl

Deadpool’s lost some fights for some pretty stupid reasons before, often getting distracted by his own warped sense of reality, or becoming more fixated on telling jokes than fighting back. Unfortunately for him, his fight against Squirrel Girl was another such encounter, where he was so baffled by her appearance that he kept trying to figure out what her name was and rationalize why she was a squirrel woman rather than actually fighting her.

Everyone knows that Squirrel Girl doesn’t lose, though, so Wade can’t be too ashamed about this defeat. Thanos, Dr. Doom, and Wolverine have all fallen at the furry claws of Squirrel Girl, so Deadpool is in good company. He only fought her in the first place due to a misunderstanding. Deadpool mistakenly thought she wasn’t registered under the Superhero Registration Act. Squirrel Girl cleared up that misunderstanding by offering a beat down first, and then an explanation later.

Hulk

One fight that was weird even by Deadpool’s standards was one of his numerous encounters with Hulk. Deadpool deliberately angered Bruce Banner to make him transform into the Hulk. This bizarre battle was different. Deadpool was actually hoping the Hulk would kill him here. It all went down in Deadpool #39, but Hulk was too confused to immediately go all out.

Deadpool lied to him and said there were bombs set to go off every hour due to a transmitter in Wade’s body, and the only way to stop it was death. Hulk was convinced and reluctantly killed Deadpool, but it wasn’t enough to stop his healing ability. Once Hulk realized Deadpool lied to him, he became angrier and smashed Deadpool’s head to bits with one punch. It was a solid defeat, but still not enough to stop Deadpool from regenerating.

Cable

Cable and Deadpool had their own comic series for a while. But like all of Deadpool’s allies, Cable is also not averse to challenging him either. There’s usually not much animosity behind their scuffles; it’s more just knowing they can afford to fight because they can both take it pretty well. Cable’s quickest and easiest defeat of Deadpool came during Marvel’s first Civil War event.

Given all the heroes affected by the story, Cable wasn’t in a joking mood this time around. Electing to fight for the pro-registration side, Deadpool went after the heroes refusing to register and tried to take them all on with a tranquilizer gun. Cable finally broke up the action and tried to reason with Deadpool, but Wade just tried to shoot his buddy too. Cable’s shield reflected the darts back at Deadpool. It wasn’t the end to the conflict Cable had wanted, but it helped the other heroes restrain Deadpool.

Daredevil

Deadpool was hunting a shapeshifter and believed he found it when he spotted Daredevil. Confident it wasn’t actually the hero, Deadpool opened fire. Once Daredevil began dodging the bullets, Wade realized his mistake. Sure, it was a misunderstanding, but that wasn’t something Daredevil was really in the mood to discuss. Deadpool just wanted to extricate himself from the mistaken fight as quickly as possible, but he couldn’t fight his way past Daredevil.

After getting beat down, Deadpool tried to explain about the shapeshifter, but Daredevil just thought he was imagining it and hogtied him in the middle of the street. Realizing he’d just have to take the loss and move on, Deadpool slipped his restraints by breaking his fingers, then shot a nearby civilian, so Daredevil had to stop and take the guy to the hospital. With Daredevil preoccupied, Deadpool ran off after his true quarry.

Deadpool

Deadpool can’t even help losing to himself. Like many heroes, he has counterparts of himself from other dimensions, and in the storyline, Deadpool Kills Deadpool, he met each of them for a crossover. Lady Deadpool, Kidpool, and Dogpool were all pretty self-explanatory, but in their own worlds, they all just considered themselves to be plain old Deadpool. So each time one of them killed the other (which was a lot), another Deadpool technically was defeated.

This started off with just one Deadpool causing trouble; an evil Leather Deadpool. Dogpool wound up dying in the battle. The original Wade didn’t take kindly to that, though, and killed his Leather self in brutal fashion after literally splitting him in half. That was hardly the end of things, as many more Deadpools would bite the dust before everything settled. Panda Deadpools, Samurais, and all other sorts got taken out by one Deadpool or another.

Moon Knight

Moon Knight and Deadpool wound up meeting in Vengeance of the Moon Knight issues #7 and 8. Deadpool took this fight more seriously than most. Deadpool had been hired to end the life of a man who was already dying, while Moon Knight was pretty strongly opposed to someone getting murdered on his watch. Their fight began in the hospital where the dying man was staying, and Moon Knight got the early advantage with some acrobatics that knocked Wade around.

Just as Deadpool got serious and was about to reciprocate, he got distracted by a hot nurse and Moon Knight punched him out of a window. Not the best showing, but that wasn’t the end of their battle either. They met up for round two at a carnival. After getting knocked around by a roller coaster, Moon Knight chased Deadpool into a room of fun house mirrors. Moon Knight smashed up the mirrors, and soon diced up Deadpool with a sword, winning two rounds in a row.

Punisher

Deadpool isn’t the only one who’s fought everyone at Marvel in one story. The Punisher did as well, and he’s arguably even more dangerous since he’s never really had any qualms about indulging in torture and murder to dispatch his opponents. It’s probably unsurprising that Punisher’s kill count was high. Punisher’s story featured the characters of Marvel getting turned into zombies thanks to a virus, and as one of the last remaining immune people, he took it upon himself to save the world by ridding it of the undead.

Deadpool happened to be one of the zombies, but he still had his healing factor, so Punisher couldn’t just kill him once. Frank had to kill Wade over and over again to the point it became a running joke in the story. Frank recounts how he has had to shoot Deadpool, bury him, burn him, and even feed him to wild animals.

Thor

While there have certainly been other heroes to lift Mjolnir, Deadpool is not a name fans could count among the characters considered worthy to wield the hammer. Deadpool had the signature helmet and a knockoff hammer to fly around with, but he wasn’t Thor. And the real Thor wasn’t pleased to see Deadpool making a mockery of the name.

The two clashed, but Wade was no match for the god. Deadpool got knocked around and lost his hammer, but didn’t lose his enthusiasm for the fight. Thor snatched up the second hammer and swung both weapons, sandwiching Deadpool’s head between them. It was enough to knock Deadpool out, and knock the Thor impersonation out of the mercenary.

Black Widow

During a time when the Thunderbolts had decided to make Deadpool their next target, he was taking on the whole team at once and having a tough time of it. But as often happens to Wade, he got distracted from the severity of the fight when other things caught his attention — namely the fact that Black Widow was a woman. Once she unmasked, it was all he could think about. At that point, Deadpool didn’t care about war anymore and wanted to give love a chance. He bombarded Black Widow with romantic advances, but neglected to keep his eyes on the other Thunderbolts.

Like in the situation with Moon Knight, Deadpool’s distraction led to his defeat, this time by the Headsman decapitating him. Deadpool was so enamored by Black Widow that she could have left him in defeat right there, and he likely would have died. But finding his affection sort of sweet, she reattached his head and revived him. So it was a victory for conquering Black Widow’s heart, but a defeat in regard to the whole “getting his head chopped off” thing.

Moonstone As Ms. Marvel

When Norman Osborn was forming his own version of the Avengers, he was unable to interest legitimate heroes into joining his cause. Osborn disguised supervillains as popular heroes. One of the villains making a real go at being a hero was Moonstone, who was operating as Ms. Marvel. The Deadpool fight was over some telepathic babies that he had stolen from the new Ms. Marvel.

She tracked him down, and it was a brief fight, since Deadpool forgot his opponent was bulletproof, which eliminated a big part of his fighting arsenal. He got bashed around a bit before latching onto her, so she took off to the air with Deadpool hanging on. Once they were high up, she let him go, and Deadpool’s last moments in the fight were remembering he can’t fly.

Black Panther

While everyone was picking sides in Civil War II, Deadpool paid a visit to the Avengers base. Black Panther stopped Deadpool for a word and made his distrust of Wade clear with a backhand across the face to kick off the fight. Deadpool seemed ticked off, but that did little to stop him from getting beaten down. Black Panther was the superior hand-to-hand fighter, so Deadpool resorted to tricks in an attempt to gain a psychological advantage.

Wade pestered T’Challa by spoiling Game of Thrones, kicking him between the legs, and even taking an intermission for a bathroom break. Maybe irritating Black Panther just motivated him further, though, because he fought through all the agitation and pushed Wade back — right out of a window to be exact. With shards of glass impaled in his body, and some clearly broken bones, Deadpool ran off as Black Panther promised to kill him in the future.

Colossus

Thanks to the Deadpool movie, this is easily one of the better-known fights for Wade. Sure, they’ve fought in the comics as well, but he didn’t fare much better there. Negasonic Teenage Warhead and Colossus showed up from the X-Men, and they made for some of the best moments in the movie, including Deadpool attempting to fight them.

Negasonic Teenage Warhead didn’t even have to get involved and just got to sit on the sidelines and laugh at Deadpool. In fact, Colossus didn’t have to do much either, since Deadpool did the majority of the damage to himself. The X-Men just wanted to take Deadpool in, but he thought he could find a way to damage Colossus’ metal exterior. Instead, Wade just wound up breaking his own hands and getting beaten so senseless that he had to cut off one of his own hands just to get away.

Batman

In the 2006 edition of the Superman/Batman comic that showed the early years of both heroes, a lot was packed into the issue. This included the alternate versions of Ultraman and Owlman. Deathstroke also showed up, but he had an alternative counterpart too, who was pretty clearly meant to be Deadpool. DC played off the mistaken assumption that Deadpool started off as a parody of Deathstroke.

Deathstroke’s alternative counterpart still had the Deathstroke color scheme, but his personality was identical to Deadpool’s, and he was shown to be capable of healing from wounds. Every time this alternate Deathstroke tried to introduce himself, he got cut off right as he said “I’m Dea—”. Those remaining letters could have spelled out Deathstroke, but based on his personality, readers knew who he really was. In the end, Batman got sick of him and decided to knock him out him rather than listen to any more of his jokes.